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October 3, 2025Annals of Clinical Microbiology and AntimicrobialsOpen Access

Heteroresistance is associated with mutations during low concentration of tigecycline therapy in multiple-resistant Klebsiella pneumoniae

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Authors

QZQiaoyu ZhangLZLimin ZhengLWLi‐Rong Wen

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Overview

Experimental analysis reveals tigecycline promotes heteroresistance in K. pneumoniae, indicating significant treatment challenges.

Key Points

  • Heteroresistance to tigecycline was induced in K. pneumoniae strains during treatment, leading to increased resistance.
  • Mutations in ramR, acrR, and rpsJ genes correlated with the emergence of tigecycline heteroresistance in K. pneumoniae.
  • The minimal inhibitory concentration of tigecycline remained elevated in resistant strains after exposure to low concentrations.
  • Combination therapies with polymyxin B and amikacin showed effectiveness against resistant subpopulations arising from tigecycline.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68e02f2cf0e39f13e7fa1fe5https://doi.org/10.1186/s12941-025-00815-6
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