October 3, 2025

Double-edged mitophagy: balancing inflammation and resolution in lung disease.

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This review demonstrates mitophagy's context-dependent effects on inflammation in lung disease, suggesting new interventions.

Mitophagy plays a protective role in lung inflammation, suppressing the NLRP3 inflammasome and pyroptosis.
Excessive mitophagy can lead to mitochondrial fragmentation and necroptosis, complicating treatment strategies.
In vivo and in vitro studies highlight mitophagy's dual role, necessitating careful therapeutic targeting.
Addressing tissue-specific mitophagy challenges could enhance interventions for inflammatory lung diseases.

Tian et al. (2025) studied this question.

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October 3, 2025

View Full Paper

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Authors

This review demonstrates mitophagy's context-dependent effects on inflammation in lung disease, suggesting new interventions.

Mitophagy plays a protective role in lung inflammation, suppressing the NLRP3 inflammasome and pyroptosis.
Excessive mitophagy can lead to mitochondrial fragmentation and necroptosis, complicating treatment strategies.
In vivo and in vitro studies highlight mitophagy's dual role, necessitating careful therapeutic targeting.
Addressing tissue-specific mitophagy challenges could enhance interventions for inflammatory lung diseases.

Tian et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark