October 3, 2025Molecular Systems BiologyOpen Access

Transition between cell states of sensitivity reveals molecular vulnerability of drug-tolerant cells

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Observational analysis reveals that drug-tolerant cells exhibit apoptosis-resistance, highlighting their vulnerability to necroptosis.

Drug-tolerant cells show reduced capacity to activate caspase-8, indicating a resistance mechanism.
Drug-tolerant cell state displays higher levels of RIPK3 expression, suggesting vulnerability to necroptosis.
Transitions between drug-sensitivity states in cancer cells enhance treatment efficacy compared to sustained therapy.
Compartmental modeling elucidates the coexistence of drug-sensitivity states and their impact on treatment response.

Peyre et al. (2025) studied this question.

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