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October 2, 2025Clinical & Translational OncologyOpen Access

A topical nociceutical formulation ameliorates chemotherapy-induced peripheral neuropathy: a pilot randomized clinical study

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Authors

SSSonia ServitjaMCMaria Castro-HenriquesIÁIgnacio Álvarez

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Overview

Pilot randomized clinical study shows the formulation lowers CIPN incidence in hands, improving quality of life.

Key Points

  • A topical nociceutical formulation significantly reduced CIPN incidence in hands, improving patients' quality of life.
  • In the nociceutical group, 13% developed CIPN in hands compared to 32% in the moisturizing group, indicating effectiveness.
  • Participants using the nociceutical formulation experienced an increase in the number of chemotherapy cycles without CIPN symptoms.
  • Reduction of bothersome neuropathic symptoms was observed, with only 39% reporting issues compared to 60% using moisturizing cream.

Cite This Study

Servitja et al. (2025) studied this question.

synapsesocial.com/papers/68de8eaeaa6cec72c69ea8fahttps://doi.org/10.1007/s12094-025-04062-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Temperature-controlled hand-foot cooling for prevention of chemotherapy-induced polyneuropathy (CIPN): Updated real-world data collection in 600 patients.2026
  2. 2Limb Compression Therapy and Chemotherapy‐Induced Peripheral Neuropathy in Women With Gynecologic Cancers: A Prospective Self‐Controlled Study( <scp>NEURO</scp> ‐ <scp>GLOVE</scp> Trial)2026
  3. 3Abstract IA003: Prevention of taxane-induced peripheral neuropathy2025
  4. 4The Efficacy and Safety of Traditional Chinese Medicine Qufenghuoxue Formula on Peripheral Neuropathy Induced by Paclitaxel in Advanced Lung Cancer：A Randomized Clinical Trial2025
  5. 5Percutaneous Peripheral Nerve Stimulation in Chemotherapy-Induced Neuropathy: A Case Report2025