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October 2, 2025CancersOpen Access

Impact of Somatic Gene Mutations on Prognosis Prediction in De Novo AML: Unraveling Insights from a Systematic Review and Meta-Analysis

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Authors

AEAmal ElfatihNANisar AhmedLSLuma Srour

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Overview

This meta-analysis reveals that somatic gene mutations influence prognosis in acute myeloid leukemia patients, indicating the need for targeted risk assessment strategies.

Key Points

  • Mutations in somatic genes affect prognosis and survival outcomes in de novo AML patients.
  • Significant findings include that FLT3-ITD mutations consistently correlate with worse overall survival and relapse-free survival.
  • The study evaluated 53 somatic gene mutations across 80 studies involving over 20,000 AML patients.
  • Results suggest that specific mutations like CEBPAdm may offer favorable outcomes while others indicate poorer prognoses.

Cite This Study

Elfatih et al. (2025) studied this question.

synapsesocial.com/papers/68de84bb5b556a9128e1baf1https://doi.org/10.3390/cancers17193189
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Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Measuring inconsistency in meta-analyses2003 · 64,137 citations