The gut-vascular axis in diabetes: exploring impaired blood flow, cardiovascular disease, and peripheral arterial complications

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Impaired blood flow and vascular complications are linked to microbial dysbiosis in type 2 diabetes.
Key factors like short-chain fatty acids and SGLT2 inhibitors influence vascular health and insulin resistance.
Evidence shows significant variability in gut microbiota profiles, calling for personalized treatment approaches.
Microbiome-based therapies, including probiotics and fecal microbiota transplantation, show promise for diabetic vascular disease.

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This comprehensive review explores vascular complications in type 2 diabetes, highlighting microbial dysbiosis and potential therapeutic strategies.

Pandian et al. (2025) studied this question.

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This comprehensive review explores vascular complications in type 2 diabetes, highlighting microbial dysbiosis and potential therapeutic strategies.