October 2, 2025Antiviral TherapyOpen Access

Best practices for screening, testing, diagnosing, and treating patients with hepatitis D (delta) virus based on global expert review and recent guidelines

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Discussion

Expert review updates screening and antiviral therapy recommendations for hepatitis D virus infection, indicating systematic screening is vital.

Systematic screening for hepatitis D virus is emphasized for all HBsAg-positive individuals, improving diagnosis rates.
The consensus recommends bulevirtide as a long-term monotherapy for effective viral suppression.
Therapeutic strategies include a focus on sustained HDV-RNA suppression and potential loss of HBV surface antigens.
Combination therapy with bulevirtide and pegylated interferon alpha may be beneficial in select cases, adapting to individual tolerability.

Cornberg et al. (2025) studied this question.

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Expert review updates screening and antiviral therapy recommendations for hepatitis D virus infection, indicating systematic screening is vital.