Computational Markers of Altered Social Interaction and Cognition in Methamphetamine Use Disorder

Computational modeling of a 10-trial trust game in 49 individuals with methamphetamine use disorder (IMUD) and 49 non-user controls revealed higher irritation, lower guilt, and reduced Theory of Mind in IMUD. These traits did not affect their own earnings but reduced partners’ earnings. Furthermore, lower guilt correlated with addiction severity. These findings suggest a more self-oriented decision-making strategy in IMUD and highlight guilt reduction as a potential computational clinical marker.