Intratumoral administration of engineered circRNAs encoding cytosine deaminase-uracil phosphoribosyltransferase (CDUPRT) and IL-15 elicit superior antitumor efficacy

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Intratumoral administration of circRNA enhances antitumor efficacy with minimal systemic toxicity.
The combination of circCDUPRT and prodrug 5-fluorocytosine shows significant tumor reduction in models.
Engineered circRNA demonstrated stability and sustained protein expression in treatment applications.
The study highlights the potential of circRNA as a cost-effective delivery system for immunotherapy.

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Gene-directed enzyme prodrug therapy and engineered circRNAs improve antitumor response, suggesting new avenues in immunotherapy.

Niu et al. (2025) studied this question.

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