October 2, 2025Frontiers in ImmunologyOpen Access

Neoadjuvant outperforms adjuvant regimens in resectable advanced Chinese melanoma patients: lymph node preservation as a key immunological advantage

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Discussion

Retrospective analysis shows neoadjuvant therapy improves recurrence-free survival in melanoma, suggesting benefits over adjuvant methods.

Neoadjuvant therapy significantly prolonged recurrence-free survival compared to adjuvant therapy.
The adjusted hazard ratio was 2.02, indicating a notable benefit for neoadjuvant treatment.
This analysis included 172 patients with advanced melanoma, demonstrating diverse treatment responses.
Surgery-related adverse events occurred in 50% of patients, reflecting the challenges in managing treatment.

Hou et al. (2025) studied this question.

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Retrospective analysis shows neoadjuvant therapy improves recurrence-free survival in melanoma, suggesting benefits over adjuvant methods.