Detection of minimal residual disease after induction chemotherapy and autologous HSCT and its clinical significance in multiple myeloma

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Analysis reveals minimal residual disease frequency and prognostic significance in multiple myeloma, highlighting treatment management implications.

The frequency of MRD-negative status post-induction therapy was found to be 35.7%, and increased to 56.7% after autologous HSCT.
A notable decrease in abnormal plasma cells was observed, with conversion of MRD-positive cases occurring during treatment.
Patients with more than 0.01% plasma cells post-induction experienced over a 2-fold increase in progression rates.
Monitoring MRD status is crucial for effective patient management and decision-making regarding maintenance treatment.

Чулкова et al. (2025) studied this question.

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View Full Paper

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Authors

Analysis reveals minimal residual disease frequency and prognostic significance in multiple myeloma, highlighting treatment management implications.

The frequency of MRD-negative status post-induction therapy was found to be 35.7%, and increased to 56.7% after autologous HSCT.
A notable decrease in abnormal plasma cells was observed, with conversion of MRD-positive cases occurring during treatment.
Patients with more than 0.01% plasma cells post-induction experienced over a 2-fold increase in progression rates.
Monitoring MRD status is crucial for effective patient management and decision-making regarding maintenance treatment.

Чулкова et al. (2025) studied this question.

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