October 2, 2025Open Access

Structural Magnetic Resonance Imaging and Genome-Wide Transcriptional Profiling Reveal Intergenerational Vulnerability in a Mouse Model of Preconceptional Stress

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Found associations between maternal stress and anxiety-like behaviors in offspring, indicating long-term risks.
Adult offspring exhibited thalamic and striatal hypotrophy with notable cortical hypertrophy, showcasing structural changes.
Risk factors were assessed using high-resolution neuroimaging and RNA sequencing, identifying sex-divergent pathways.
Study offers insights into maternal depression's impact on offspring, emphasizing the need for preventive measures.

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Implication

Observational analysis reveals thalamostriatal reductions linked to anxiety behavior in mice, indicating neurodevelopmental risks from maternal stress.

Cite This Study

Richetto et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a2169f https://doi.org/10.21203/rs.3.rs-7535749/v1

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Implication

Observational analysis reveals thalamostriatal reductions linked to anxiety behavior in mice, indicating neurodevelopmental risks from maternal stress.

Structural Magnetic Resonance Imaging and Genome-Wide Transcriptional Profiling Reveal Intergenerational Vulnerability in a Mouse Model of Preconceptional Stress

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Discussion

Implication

Cite This Study

Structural Magnetic Resonance Imaging and Genome-Wide Transcriptional Profiling Reveal Intergenerational Vulnerability in a Mouse Model of Preconceptional Stress

Key Points

Discussion

Implication

Cite This Study

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