Resistance of ERG24 sterol C-14 reductase to heterocyclic amine antifungals

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Mutations in ERG24 induce fungicide resistance in wheat powdery mildew, indicating alternative antifungal options.

Resistance mutations in ERG24 affect wheat powdery mildew's response to antifungals.
Mutations show minimal impact on yeast growth, suggesting potential for developing new treatments.
Predictive modeling reveals that antifungals may obstruct substrate access to the catalytic site.
Findings may guide the design of novel antifungals targeting ERG24 as alternatives to existing inhibitors.

Arnold et al. (2025) studied this question.

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Mutations in ERG24 induce fungicide resistance in wheat powdery mildew, indicating alternative antifungal options.

Resistance mutations in ERG24 affect wheat powdery mildew's response to antifungals.
Mutations show minimal impact on yeast growth, suggesting potential for developing new treatments.
Predictive modeling reveals that antifungals may obstruct substrate access to the catalytic site.
Findings may guide the design of novel antifungals targeting ERG24 as alternatives to existing inhibitors.

Arnold et al. (2025) studied this question.

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