October 2, 2025Circulation Heart Failure

Plasma Proteome Analysis Identifies Vascular Endothelial Growth Factor Receptor 1 as a Prognostic Biomarker in Cardiogenic Shock

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Authors

CJChristian JungDüsseldorf University Hospital ALAlexander LangDüsseldorf University Hospital DDDragos Andrei DuseDüsseldorf University Hospital

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Implication

Proteomic profiling reveals VEGFR1's prognostic relevance for 180-day survival in cardiogenic shock patients, suggesting potential therapeutic pathways.

Key Points

Elevated VEGFR1 levels in patients with cardiogenic shock predict higher mortality risk after 180 days.
In independent validation, nonsurvivors had significantly higher VEGFR1 levels compared to survivors.
Cox regression analysis showed VEGFR1 as an independent predictor of 180-day mortality risk, beyond standard clinical indicators.
Continuous monitoring of VEGFR1 levels in patients illustrates its potential as an early prognostic biomarker.

Cite This Study

Jung et al. (2025) studied this question.

synapsesocial.com/papers/68de68ea83cbc991d0a214fd https://doi.org/10.1161/circheartfailure.125.012890

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Implication

Proteomic profiling reveals VEGFR1's prognostic relevance for 180-day survival in cardiogenic shock patients, suggesting potential therapeutic pathways.

Plasma Proteome Analysis Identifies Vascular Endothelial Growth Factor Receptor 1 as a Prognostic Biomarker in Cardiogenic Shock

Discussion

Member takes

Implication

Key Points

Cite This Study

Plasma Proteome Analysis Identifies Vascular Endothelial Growth Factor Receptor 1 as a Prognostic Biomarker in Cardiogenic Shock

Discussion

Member takes

Implication

Key Points

Cite This Study

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