October 2, 2025Open Access

Novel Tissue Mechanics-Guided Cellular Flows Enable the Evolution of Feather Follicles

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Novel cellular flows and tissue mechanics guide epithelial morphology during feather follicle development.
Mechanical activation of YAP drives cell folding and leads to the formation of key structures in feathers.
Topological transformation modeling indicates that morphogenesis in feathers is mechanistically interconnected.
Rigid epithelial sheets during scale development limit necessary cellular flows for further transformations.

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This analysis reveals how tissue mechanics and cellular flows guide feather follicle evolution, indicating key morphogenetic processes.

Harn et al. (2025) studied this question.

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