A Comparative Study of 157Gd and 10B Effect in a Carborane-Based Theranostic Agent for Membrane-Targeted Carbonic Anhydrase IX Inhibition and MRI-Guided Neutron Capture Therapy in Mesothelioma Treatment
This comparative study shows inhibited tumor growth in mesothelioma using carbonic anhydrase IX inhibition, indicating potential for innovative cancer therapies.
Key Points
Tumor regrowth was completely inhibited after treatment with 157Gd-10B-CA-SF, demonstrating strong anti-cancer effects.
In vitro studies indicated a 10-fold higher boron uptake in AB22 mesothelioma cells compared to healthy tissue, highlighting selective binding.
In vivo experiments showed reduced tumor growth in treated mice, confirming the effectiveness of both 157Gd and 10B for mesothelioma therapy.
The Gd-B-CA-SF platform's design integrates neutron capture efficacy and MRI compatibility, supporting its translational potential.