October 2, 2025AgingOpen Access

L-β-aminoisobutyric acid (L-BAIBA) in combination with voluntary wheel running exercise enhances musculoskeletal properties in middle-age male mice

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Discussion

Combination of l-β-aminoisobutyric acid and exercise enhances musculoskeletal properties in mice, suggesting beneficial interactions.

Soleus muscles in VWR+L-BAIBA mice were larger and contracted more forcefully compared to controls.
These mice showed improved bone properties, indicated by lower marrow adiposity and better trabecular connectivity.
Exercise alone did not enhance muscle fatigue resistance as effectively as the combination of exercise and L-BAIBA.
QTc interval was slightly prolonged in VWR+L-BAIBA group, indicating potential cardiac effects.

Vallejo et al. (2025) studied this question.

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