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October 1, 2025Natural Product Research

Isolation of a novel bufadienolide, bufovende A, and seven known analogs from Venenum bufonis with inhibitory activity on hepatic stellate cell activation

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Authors

HLHuijing LvCLChengjin LiQLQ H Li

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Overview

Isolation of bufadienolides reveals their potential to inhibit hepatic stellate cell activation, suggesting antifibrotic applications.

Key Points

  • Bufovende A and seven analogs were isolated from Venenum bufonis, demonstrating significant antifibrotic activity.
  • Inhibition rates were notable for α-SMA (61.33%) and COL1A1 (57.46%) at non-cytotoxic concentrations of 0.2 μM.
  • The study assessed the antifibrotic potential using the LX-2 human hepatic stellate cell line, showing downregulation of fibrosis markers.
  • These findings highlight bufadienolides as promising leads for antifibrotic therapy, with bufovende A being particularly noteworthy.

Cite This Study

Lv et al. (2025) studied this question.

synapsesocial.com/papers/68dd9537fe798ba2fc499866https://doi.org/10.1080/14786419.2025.2567641
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