This review highlights the roles of long non-coding RNAs in breast cancer, suggesting strategies to overcome their heterogeneity in precision medicine.
Key Points
Long non-coding RNAs show diverse roles in breast cancer, either promoting or inhibiting tumor-related processes.
Their functional heterogeneity complicates therapeutic applications, highlighting the need for improved classification and targeted research.
Strategies like CRISPR/Cas and single-cell sequencing are vital for understanding lncRNA functions and enhancing clinical utility.
Contextual factors such as subtype differences and the tumor microenvironment significantly influence lncRNA behavior in breast cancer.