This study found elevated interleukin-1β and interleukin-10 levels in patients infected with Helicobacter pylori, indicating inflammation.
Background: Helicobacter pylori is a human pathogen colonizes epithelial stomach. In the development of diseases, cytokines play crucial functions and may have an impact on the disease process. Objectives: To estimate the levels of interleukin-1β (IL-1β), interleukin-10 (IL-10), and cytotoxin associated gene (CagA) IgG in individuals infected with H. pylori . Materials and Methods: The study, performed from November 2022 to April 2023, included 66 individuals divided into two groups: 40 patients (60% male, 40% female patients) with a mean age of 45.25 who had positive H. pylori stool antigen tests, and 26 healthy individuals as a control (50% males, 50% females) mean age 45.26. Two types of samples had been collected: stool samples for the quick identification of H. pylori antigen by the immunochromatographic cassette, and 5 mL of venous blood to quantitatively estimate serum H. pylori IgG, H. pylori CagA IgG, IL-1β, and IL-10 using sandwich enzyme linked immunosorbent assay technology. Results: There was a highly significant increase ( P = 0.01) in H. pylori IgG titers in the patients (male 89.49 ± 24.03, female 93.35 ± 25.18) compared to the control (male 47.92 ± 20.13, female 62.26 ± 19.03), and H. pylori CagA IgG (male 354.7 ± 29.4, female 356.2 ± 23.0) compared to control (male 229.5 ± 25.4, female 219.3 ± 27.1). Also, there was a highly significant increase ( P = 0.01) in the levels of IL-1β and IL-10 in patients compared to control. Conclusion: The individuals infected with H. pylori had elevated levels of IL-1β and IL-10.
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Ali et al. (2025) studied this question.