In vitro analysis shows antiproliferative activity of Lumbricus terrestris extracts and serine protease against MCF-7 cells, indicating potential cancer treatments.
Key Points
The study found that crude extracts of Lumbricus terrestris significantly inhibited MCF-7 cell proliferation, revealing their antiproliferative potential.
The extracts demonstrated weak cytotoxicity with IC50 values of 228 μg/ml for MCF-7 cells and 319 μg/ml for normal NHF cells.
Serine protease isolated from earthworms exhibited moderate cytotoxicity against both MCF-7 and NHF cell lines, with IC50 values ranging from 21-200 μg/ml.
These findings support the potential use of earthworm extracts and enzymes as therapeutic agents in anticancer treatments.