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October 1, 2025Medical Journal of BabylonOpen Access

Effect of Levofloxacin on the Expression of adeB Efflux Pump Gene in Pseudomonas aeruginosa Isolated from the Intensive Care Unit in Babylon, Iraq

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Authors

ARAlya Amer RahiBABatool K. Al-AssadyHAHuda H. Al-Hasnawy

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Overview

Observational analysis found levofloxacin induces MexB-OprM efflux pump expression in Pseudomonas aeruginosa isolates, indicating a link to antibiotic resistance.

Key Points

  • Levofloxacin significantly upregulates the MexB-OprM efflux pump genes in Pseudomonas aeruginosa.
  • About 25% of blood specimens tested positive for Pseudomonas aeruginosa, showing 100% resistance to several antibiotics.
  • Molecular tests revealed that all isolates carried the OprM gene, with a significant proportion also carrying the MexB gene.
  • The upregulation of MexB correlates with increased levofloxacin minimal inhibitory concentration values, underscoring resistance mechanisms.

Cite This Study

Rahi et al. (2025) studied this question.

synapsesocial.com/papers/68dd91dafe798ba2fc499515https://doi.org/10.4103/mjbl.mjbl_631_24
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Detecting the Efflux Pumps Gene (mexB and oprM ) in MDR Pseudomonas Aeruginosa Isolated from Wound Infection2024
  2. 2Detection of Fluoroquinolones Antibiotic Resistant in Pseudomonas Aeruginosa Isolates2025
  3. 3Molecular detection of the MexA efflux pump gene in Pseudomonas aeruginosa isolated from Diyala Province2025
  4. 4Assessment of In vitro activity of Levonadifloxacin against clinical bacterial isolates in patients admitted in ICU in a tertiary care hospital2025
  5. 5Evaluation of the relationship between quorum sensing system genes and antibiotic resistance in isolated Pseudomonas aeruginosa from cystic fibrosis patients2025