October 1, 2025JAMA Network OpenOpen Access

Methods of Pediatric Post–COVID Condition Studies in High-Impact Journals

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Only 24 of 426 reviewed studies focused on post–COVID condition in pediatric populations, uncovering significant methodological gaps.
Of the 24 analyzed studies, 38% employed test-negative controls, while 63% did not, indicating a reliance on less robust methodologies.
Just 4 out of 9 studies using test-negative controls utilized matched control designs, demonstrating a critical need for managing confounding variables.
Demographic factors like sex and psychiatric history were often underreported, indicating inconsistencies in patient profiles and potential oversights in pediatric post–COVID condition assessments.

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Implication

Evidence review highlights varied methodologies in pediatric post–COVID condition studies, suggesting improvements. Prospective cohort designs with test-negative controls are crucial for clearer definitions.

Cite This Study

Rozelle et al. (2025) studied this question.

synapsesocial.com/papers/68dd91dafe798ba2fc4992da https://doi.org/10.1001/jamanetworkopen.2025.29659

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Methods of Pediatric Post–COVID Condition Studies in High-Impact Journals

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Discussion

Implication

Cite This Study

Methods of Pediatric Post–COVID Condition Studies in High-Impact Journals

Key Points

Discussion

Implication

Cite This Study

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