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October 1, 2025MedicineOpen Access

Identification and validation of immune-associated gene signatures for prognostic prediction in acute myeloid leukemia

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Authors

CXChunxin XuHQHaiyan QiLYLiuqing Yang

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Overview

Study identifies immune-associated genes, creating a prognostic model for overall survival in acute myeloid leukemia patients.

Key Points

  • A 9-gene signature model improved overall survival predictions for acute myeloid leukemia patients significantly.
  • The model demonstrated high predictive accuracy, with area under the curve values indicating robust performance through various survival periods.
  • Differentially expressed immune-associated genes were identified between acute myeloid leukemia and healthy samples using transcriptome data.
  • Multiple independent datasets were employed to validate the prognostic model, enhancing its potential for patient stratification and personalized treatment.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68dd91d5fe798ba2fc4990b1https://doi.org/10.1097/md.0000000000044767
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