October 1, 2025Open Access

Sickle cell visualization in vivo in humans: microvascular occlusion formation and hemorheological indices

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Novel imaging technique shows blood flow changes in sickle cell disease patients, highlighting occlusion mechanisms.

Sickle cell patients showed significantly fewer fast-flowing vessels compared to controls, indicating impaired blood flow.
Patients exhibited more adhered red blood cells and microvascular occlusions before transfusion, suggesting increased vessel blockage.
Post-transfusion, the sickle cell subjects had improved blood flow dynamics with more fast-flowing vessels and fewer adhered cells.
The study emphasizes the role of hemorheological indices in assessing vascular dysfunction in sickle cell disease.

Morakis et al. (2025) studied this question.

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