Design, Synthesis and In Vitro Biological Assessment Of Novel 2-(3-Alkyl/Aryl-4,5-Dihydro-1h-1,2,4-Triazol-5-One-4-Yl)AzomethinePhenyl 2,5-Dichlorobenzenesulfonates Molecules as Antioxidant and Antibacterial Agents

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Synthesis of new triazole compounds with antioxidant and antimicrobial properties, suggesting enhanced therapeutic potential.

Compounds 4a-i exhibited significant antioxidant properties, showing metal chelation activity comparable to α-tocopherol.
Among the tested compounds, 4a demonstrated superior antimicrobial activity compared to some standard antibiotics.
The synthesis of these new triazole derivatives achieved yields exceeding 90%, ensuring effective production of targeted compounds.
The study utilized NMR and IR spectroscopy for the structural elucidation of the synthesized compounds, confirming their identities.

Aytemiz et al. (2025) studied this question.

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View Full Paper

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Synthesis of new triazole compounds with antioxidant and antimicrobial properties, suggesting enhanced therapeutic potential.

Compounds 4a-i exhibited significant antioxidant properties, showing metal chelation activity comparable to α-tocopherol.
Among the tested compounds, 4a demonstrated superior antimicrobial activity compared to some standard antibiotics.
The synthesis of these new triazole derivatives achieved yields exceeding 90%, ensuring effective production of targeted compounds.
The study utilized NMR and IR spectroscopy for the structural elucidation of the synthesized compounds, confirming their identities.

Aytemiz et al. (2025) studied this question.

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