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October 1, 2025CellsOpen Access

Circulating and Tissue Galectin-3 in Gastrointestinal Inflammation: Clinical Significance and Biomarker Potential

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Authors

VBVesna BrzačkiAJAndriana JovanovićARAndrija Rančić

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Overview

Observational analysis highlights the role of galectin-3 in inflammation and fibrosis, suggesting new therapeutic avenues.

Key Points

  • Galectin-3 is linked to chronic intestinal inflammation in gastrointestinal disorders, including inflammatory bowel disease.
  • Research shows that inhibiting galectin-3 significantly reduces fibrosis and inflammation in various conditions.
  • Galectin-3 is involved in immune regulation and tissue remodeling, playing a crucial role in diseases like NASH and liver fibrosis.
  • The protein is linked to the activation of the NLRP3 inflammasome, which contributes to the progression of intestinal inflammation.

Cite This Study

Brzački et al. (2025) studied this question.

synapsesocial.com/papers/68dd89e6fe798ba2fc49820fhttps://doi.org/10.3390/cells14191521
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