Mediation of symptom severity in the relationship between white matter alterations and functional impairment in attention deficit-hyperactivity disorder children: an AFQ and TBSS study

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Discussion

This analysis reveals disrupted and enhanced white matter changes in ADHD children, suggesting potential biomarkers.

Functional impairment in ADHD children is influenced by white matter alterations, highlighting key areas for intervention.
Higher mean fractional anisotropy in the anterior thalamic radiation correlates with increased functional impairment.
Mediation analyses show that ADHD symptom severity plays a role in the relationship between white matter changes and impairment.
This study underscores the importance of specific white matter tracts as biomarkers in ADHD for improving clinical outcomes.

Zhang et al. (2025) studied this question.

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