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September 25, 2025Frontiers in PharmacologyOpen Access

Multi-pathway mechanisms of Liujunzi decoction in promoting glioma apoptosis and reversing drug resistance: network pharmacology and experimental validation

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Authors

JHJinxiang HuangSLShengnan LinLLLin Lei

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Overview

Network pharmacology reveals liujunzi decoction enhances apoptosis and overcomes drug resistance in glioma.

Key Points

  • Liujunzi decoction induces glioma cell apoptosis and reduces drug resistance, suggesting a new treatment strategy.
  • Using network pharmacology, 76 active ingredients were identified alongside 174 overlapping targets related to glioma.
  • Molecular docking showed strong binding between active ingredients of liujunzi decoction and core targets linked to apoptosis.
  • In vitro experiments highlighted glabridin's role in inhibiting cell viability and promoting apoptosis in glioma cells.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68d5e1ffbd7882ccb9b86583https://doi.org/10.3389/fphar.2025.1682550
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