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September 25, 2025JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIAOpen Access

Efficacy of Ticagrelor Monotherapy in Patients at High Bleeding Risk Undergoing Percutaneous Coronary Intervention: a Systematic Review

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Authors

EAErlita Nur ArifanaBZBambang Subakti Zulkarnain

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Overview

Systematic review assesses outcomes of transitioning to ticagrelor monotherapy in high bleeding risk patients, indicating potential benefits.

Key Points

  • Transition to ticagrelor monotherapy after DAPT significantly impacts clinical outcomes in high bleeding risk patients.
  • Analysis of six studies revealed critical endpoints including all-cause mortality and myocardial infarction over one year.
  • Conducted according to PRISMA guidelines, the systematic review utilized data from multiple databases, enhancing validity.
  • Findings suggest ticagrelor monotherapy could be a viable alternative for managing bleeding risks in post-PCI care.

Cite This Study

Arifana et al. (2025) studied this question.

synapsesocial.com/papers/68d5e1fbbd7882ccb9b86243https://doi.org/10.20473/jfiki.v12i22025.174-194
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sequential administration of abbreviated (up to one month) dual antiplatelet therapy and Ticagrelor monotherapy versus standard dual antiplatelet therapy after percutaneous coronary intervention: A meta-analysis2025
  2. 2Short- Versus Standard-Duration Dual Antiplatelet Therapy After Percutaneous Coronary Intervention in Acute Coronary Syndrome: A Systematic Review and Meta-Analysis2026
  3. 3‘Aspirin versus ticagrelor for the management after coronary revascularization - a systematic review and meta‑analysis of randomised trials’2026
  4. 4Personalized Antithrombotic Therapy After Percutaneous Coronary Intervention: A Systematic Review of Risk‐Stratified Approaches2026
  5. 5Early Withdrawal of Aspirin after PCI in Acute Coronary Syndromes2025 · 77 citations