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September 25, 2025Science ProgressOpen Access

Molecular advances in early-stage and locally advanced non-small cell lung carcinoma: Shaping the future of precision oncology-systematic review

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WHWael Abdo Hassan

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Overview

This systematic review synthesizes recent molecular advances that inform diagnosis and treatment in non-small cell lung carcinoma, indicating the importance of genomic profiling and minimal residual disease detection.

Key Points

  • Actionable molecular alterations are prevalent in early-stage non-small cell lung carcinoma, enhancing the importance of routine genomic profiling.
  • Next-generation sequencing and circulating tumor DNA detection improve the prediction of relapse by identifying minimal residual disease.
  • Integrating targeted therapies and immunotherapies significantly enhances outcomes in biomarker-defined populations in perioperative settings.
  • The findings support a moderate-to-high certainty for key outcomes related to profiling and minimal residual disease, with a call for standardized testing and equitable implementation.

Cite This Study

Wael Abdo Hassan (2025) studied this question.

synapsesocial.com/papers/68d5dae1ddad3c16d46373cchttps://doi.org/10.1177/00368504251383055
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