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September 25, 2025Hospital Pharmacy

A Single Health System Retrospective Qualitative Analysis of Inpatient Apixaban and Rivaroxaban Calibrated Anti-Xa Level Monitoring and Clinical Implications

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Authors

BMBeth McCarvilleJOJennifer L. Osborn

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Overview

Qualitative analysis shows low incidence of appropriate DOAC levels in clinical practice, suggesting improvements are needed in monitoring strategies.

Key Points

  • Only 0.48% of apixaban and rivaroxaban orders led to a calibrated anti-Xa level being drawn during the study.
  • Primary reasons for obtaining DOAC levels included extreme body weight, treatment failures, and bleeding concerns.
  • Only 31.8% of levels were drawn at the correct peak time, with many leading to no changes in therapy.
  • Future research is crucial to evaluate if DOAC concentrations can have significant clinical implications.

Cite This Study

McCarville et al. (2025) studied this question.

synapsesocial.com/papers/68d5dae1ddad3c16d463723dhttps://doi.org/10.1177/00185787251372413
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