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September 25, 2025Cancer Immunology Research

Abstract PR-07: Immunosuppressive γδ T cells limit anti-tumor immunity in ICI-resistant tumors from autoimmune-prone mice

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Authors

CHChristopher B. HansenAYArabella Young

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Overview

Research demonstrates how immunosuppressive γδ T cells limit anti-tumor immunity in ICI-resistant tumors, suggesting implications for autoimmune conditions.

Key Points

  • Immunosuppressive γδ T cells in ICI-resistant tumors impair anti-tumor immunity and promote tumor growth.
  • In ICI-resistant NOD tumors, CD8+ T cells displayed a naïve-like phenotype, affecting tumor response significantly.
  • Single-cell RNA sequencing revealed increased γδ T cells, indicating their role in immune regulation and ICI resistance.
  • Targeting γδ T cells may aid in overcoming ICI resistance and improving anti-tumor responses without increasing adverse events.

Cite This Study

Hansen et al. (2025) studied this question.

synapsesocial.com/papers/68d5dabfddad3c16d463709ahttps://doi.org/10.1158/2326-6074.cimm25-pr-07
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