Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 25, 2025Cancer Immunology Research

Abstract PR-13: Myeloid checkpoint blockade potentiates radiotherapy by modulating dendritic cells and reducing Treg-driven immunosuppression

View Full Paper
Ask AI
Bookmark
Share

Authors

MCMaud CharpentierCLClaire LhuillierAAAlicia Alonso

Discussion

Loading...

Member takes

Overview

Combining checkpoint blockade with radiotherapy reduces Treg activity in breast cancer, suggesting enhanced tumor regression.

Key Points

  • The combined treatment of radiotherapy with SIRPα blockade significantly reduced Treg infiltration in tumors.
  • Enhanced regression of irradiated tumors was achieved using SIRPα blockade with radiotherapy in mouse breast cancer models.
  • Single-cell RNA sequencing revealed reduced expression of Treg activation markers in the SIRPα blockade plus radiotherapy group.
  • Targeting the SIRPα axis may improve radiotherapy efficacy by modulating dendritic cell functions affecting immune environment.

Cite This Study

Charpentier et al. (2025) studied this question.

synapsesocial.com/papers/68d5dabfddad3c16d4636fdchttps://doi.org/10.1158/2326-6074.cimm25-pr-13
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract A023: Myeloid checkpoint blockade potentiates radiotherapy by modulating dendritic cells and reducing Treg-driven immunosuppression2025
  2. 2Abstract B007: Tissue-Specific B Cell Differentiation Limits Anti-Tumor Efficacy of Radiation and Immunotherapy2025
  3. 3Radiotherapy, inflammation, and the myeloid perspective2026
  4. 4Enhancing radiation therapy by targeting CCR8+ tregs in cancer 32092025
  5. 5Pre-existing cytotoxic capacity of CD8+ and CD4+ T cells is a hallmark of richter transformation and favors response to anti-PD-1 therapy2025