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September 25, 2025Open Access

Immunological and non-immunological features specific to Long-COVID: multiple overlapping aetiologies and potential biomarkers

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Authors

FPFrédérique Ponchel

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Overview

Observational analysis highlighted distinct immunological features in long-COVID patients, suggesting potential biomarkers for stratification.

Key Points

  • Long-COVID symptoms cluster into 4 groups, indicating potential stratification for better management of patients.
  • Systemic inflammation persists over time in long-COVID patients, not linked to continuing SARS-CoV-2 infection.
  • CD4+T-cells show significant changes in exhaustion and regulation, suggesting their role in long-COVID pathology.
  • Candidate biomarkers like CRP and specific cytokines may indicate disease processes and help in targeted therapies.

Cite This Study

Frédérique Ponchel (2025) studied this question.

synapsesocial.com/papers/68d5d0feddad3c16d4635f72https://doi.org/10.1101/2025.09.22.25335153
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