September 25, 2025Open Access

Differential functional connectivity between hippocampus and prefrontal cortex is associated with heterogeneity in open field exploration

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Distinct behavioral modes in rats during open field exploration correlate with changes in brain activity.
Rats exhibited differences in theta and gamma band power related to their exploration behavior in the open field.
Communication between the hippocampus and prefrontal cortex is crucial during behavioral transitions in exploration.
Maternal immune activation intervention affects connectivity but preserves intra-regional brain activity in the hippocampus.

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Study shows differential connectivity between hippocampus and prefrontal cortex affects open field behavior, indicating distinct behavioral modes.

Munn et al. (2025) studied this question.

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Study shows differential connectivity between hippocampus and prefrontal cortex affects open field behavior, indicating distinct behavioral modes.