September 25, 2025Open Access

The Association Between Inflammatory Indices and Mortality in Patients with Moderate-to-Severe Tricuspid Regurgitation

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Retrospective cohort study finds elevated SII and NLR increase mortality risk in moderate-to-severe TR, suggesting improved risk stratification.

Elevated SII and NLR independently increase risk of all-cause mortality in patients with moderate-to-severe TR, with NLR showing stronger association.
Among 1,349 patients, 39% (523 deaths) occurred during a median follow-up of 4.9 years, highlighting significant mortality rates.
Cox regression revealed that each unit increase in SII and NLR corresponds to a respective 26% and 57% increased risk of mortality.
SII and NLR may serve as inexpensive biomarkers to enhance risk stratification and guide management in clinical settings.

Zhang et al. (2025) studied this question.

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September 25, 2025Open Access

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Authors

Retrospective cohort study finds elevated SII and NLR increase mortality risk in moderate-to-severe TR, suggesting improved risk stratification.

Elevated SII and NLR independently increase risk of all-cause mortality in patients with moderate-to-severe TR, with NLR showing stronger association.
Among 1,349 patients, 39% (523 deaths) occurred during a median follow-up of 4.9 years, highlighting significant mortality rates.
Cox regression revealed that each unit increase in SII and NLR corresponds to a respective 26% and 57% increased risk of mortality.
SII and NLR may serve as inexpensive biomarkers to enhance risk stratification and guide management in clinical settings.

Zhang et al. (2025) studied this question.

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