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September 25, 2025Open Access

Association of Non-High-Density Lipoprotein Cholesterol to High-Density Lipoprotein Cholesterol Ratio (NHHR) with Cardiovascular-Kidney-Metabolic (CKM) Syndrome Stages: Evidence from a Nationally Representative U.S. Cohort (NHANES 2005–2018)

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Authors

JQJie QinJTJiaxin TanLHLifeng Huang

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Overview

Analysis shows a positive link between NHHR and CKM syndrome stages, highlighting its potential predictive value.

Key Points

  • NHHR is significantly higher in CKM syndrome patients compared to those without it.
  • A predictive analysis revealed NHHR had the best discriminatory ability for CKM stage 2 with AUC of 0.673.
  • Age, race, and education significantly influence the relationship between NHHR and CKM syndrome.
  • Multivariate logistic regression confirmed a positive association between NHHR and CKM syndrome.

Cite This Study

Qin et al. (2025) studied this question.

synapsesocial.com/papers/68d5bd72dc445aa9033b0c60https://doi.org/10.1101/2025.09.21.25336290
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