September 25, 2025Frontiers in ImmunologyOpen Access

The role of FoxO3a in the pathogenesis of osteoarthritis and its therapeutic applications

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Discussion

This review demonstrates FoxO3a's critical involvement in osteoarthritis, highlighting potential therapeutic interventions.

FoxO3a significantly influences the onset and progression of osteoarthritis by regulating chondrocyte activities.
Regulatory mechanisms involving FoxO3a include its role in inflammatory response and oxidative stress in chondrocytes.
The expression of FoxO3a presents potential therapeutic avenues for preventing and treating osteoarthritis.
Post-translational modifications of FoxO3a affect its activity, impacting cell survival and physiological processes.

Wu et al. (2025) studied this question.

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