September 25, 2025Intensive Care MedicineOpen Access

Monocyte HLA-DR expression in septic shock patients: insights from a 20-year real-world cohort of 1023 cases

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Discussion

Cohort study reveals low monocyte HLA-DR is linked to higher mortality and infections in septic shock patients.

Low monocyte HLA-DR expression is significantly associated with increased mortality in septic shock patients.
The study analyzed data from 1023 patients, revealing that low mHLA-DR correlates with ICU-acquired infections.
Using standardized flow cytometry, the research measured mHLA-DR during the first week of ICU admission.
This analysis underscores the importance of tracking mHLA-DR trajectories for detecting persistent immune dysfunction.

Monneret et al. (2025) studied this question.

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