Establishment and Validation of High‐Performance Liquid Chromatography—Tandem Mass Spectrometry for Simultaneous Assessment of Amlodipine and Indapamide in Human Plasma

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A method validates simultaneous measurement of amlodipine and indapamide in plasma, highlighting effectiveness for hypertension treatment.

The method achieves a detection range of 0.29-17.14 ng/mL for amlodipine and 1.14-68.57 ng/mL for indapamide.
Validation showed acceptable metrics for specificity, precision, accuracy, and stability using furosemide as an internal standard.
Positive and negative electrospray ionizations were utilized for amlodipine and indapamide, respectively.
The method meets FDA and EMA guidelines, indicating its suitability for bioavailability and bioequivalence studies.

Nguyen et al. (2025) studied this question.

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A method validates simultaneous measurement of amlodipine and indapamide in plasma, highlighting effectiveness for hypertension treatment.