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September 25, 2025Frontiers in PhysiologyOpen Access

Progress in understanding how clock genes regulate aging and associated metabolic processes

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Authors

YSYanhong SuMWMeng WangJCJuan Chen

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Overview

This review uncovers how clock genes regulate circadian rhythms and metabolic disorders with aging, suggesting potential intervention strategies.

Key Points

  • Circadian rhythm disruption elevates the risk of metabolic disorders, impacting various organs and promoting dysfunction.
  • Emerging evidence highlights the role of telomere homeostasis and SIRT1 in mediating the effects of clock genes on aging.
  • The analysis addresses the decline of circadian functions with age, emphasizing the link between clock genes and metabolic health.
  • A deeper understanding of these mechanisms may enhance strategies targeting aging and associated metabolic diseases.

Cite This Study

Su et al. (2025) studied this question.

synapsesocial.com/papers/68d5bd6edc445aa9033b09e1https://doi.org/10.3389/fphys.2025.1654369
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