September 25, 2025Advanced ScienceOpen Access

Synovium‐On‐A‐Chip: Simulating the Microenvironment of the Rheumatoid Arthritis Synovium via Multicell Interactions to Target Fibroblast‐Like Synoviocytes

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Authors

WDWenya Diao JYJiao YiAnhui Medical University TDTingting DengShanghai University

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Implication

This analysis reveals enhanced inflammatory markers in fibroblast-like synoviocytes, highlighting the synovium-on-a-chip's potential in rheumatoid arthritis research.

Key Points

The synovium-on-a-chip model consistently maintains elevated levels of IL-6 and IL-8, reflecting rheumatoid arthritis synovial inflammation over 9 days.
Analyzed data from 22 blood samples and 48 synovial fluid samples confirm the inflammatory profile of the chip model compares well with actual patient tissues.
Using immunofluorescence staining and flow cytometry, the effective coculture ratio of RA FLSs, macrophages, and endothelial cells is established at 1:1:1.
The SOC model shows promise in preclinical assessments of drug efficacy, testing therapeutic agents like triptolide and celastrol for RA treatment.

Cite This Study

Diao et al. (2025) studied this question.

synapsesocial.com/papers/68d5bd69dc445aa9033b05b6 https://doi.org/10.1002/advs.202511945

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Implication

This analysis reveals enhanced inflammatory markers in fibroblast-like synoviocytes, highlighting the synovium-on-a-chip's potential in rheumatoid arthritis research.

Synovium‐On‐A‐Chip: Simulating the Microenvironment of the Rheumatoid Arthritis Synovium via Multicell Interactions to Target Fibroblast‐Like Synoviocytes

Discussion

Member takes

Implication

Key Points

Cite This Study

Synovium‐On‐A‐Chip: Simulating the Microenvironment of the Rheumatoid Arthritis Synovium via Multicell Interactions to Target Fibroblast‐Like Synoviocytes

Discussion

Member takes

Implication

Key Points

Cite This Study

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