Toxic Mechanisms of Fipronil in Human Astrocytes and the Protective Effect of Vitamin E on Fipronil‐Induced Toxicity

View Full Paper

Ask AI

Bookmark

Authors

Discussion

This research reveals fipronil induces oxidative stress and apoptosis in astrocytes, while vitamin E suggests protective effects.

Fipronil significantly reduced cell viability in human astrocytes and induced oxidative stress.
Cell treatment with fipronil increased reactive oxygen species and depleted glutathione levels, disrupting redox balance.
Vitamin E effectively mitigated fipronil's effects by restoring antioxidant defenses and reducing apoptosis.
These findings suggest the potential of vitamin E as a therapeutic agent against neurotoxicity from environmental toxins.

Chen et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark