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September 25, 2025PLOS Global Public HealthOpen Access

Characteristics and six-month viral load suppression of clients presenting with advanced HIV disease in South Africa

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Authors

EKElizabeth KachingweNMNyasha MutandaVNVinolia Ntjikelane

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Overview

Observational cohort assesses viral load suppression and client profiles in advanced HIV disease, indicating a need for tailored ART support.

Key Points

  • AHD clients have poorer viral suppression at 43% compared to 47% in non-AHD clients, despite similar retention.
  • A significant 29% of sampled clients presented with advanced HIV disease at ART initiation, linked to higher mortality and opportunistic infections.
  • Among the 1,098 clients surveyed, 72% were female, and the median age was 33, showing demographic trends in advanced HIV disease.
  • The presence of TB was notably higher in AHD clients at 42%, underlining the urgent need for improved early detection and management strategies.

Cite This Study

Kachingwe et al. (2025) studied this question.

synapsesocial.com/papers/68d5bd5ddc445aa9033afef9https://doi.org/10.1371/journal.pgph.0004927
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