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September 25, 2025ShockOpen Access

Dynamic Multi-organ Dysfunction After Trauma with Secondary Sepsis in Rats: A 6–72 hours Temporal Map Validated by Rodent-Specific MODS Scoring

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Authors

BSBaisheng SunDQDiqing QianCZCong Zhang

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Overview

Experimental analysis reveals MODS evolution and organ dysfunction timings in rats with sepsis.

Key Points

  • The Fx+CLP group showed a mortality rate of 58.33%, significantly higher than other groups.
  • Levels of interleukin-6 and interleukin-10 peaked at 24 hours in the Fx+CLP group, surpassing other groups.
  • Organ dysfunction began at 12 hours for cardiac and hepatic issues, followed by pulmonary and renal symptoms at 24 hours.
  • A validated MODS score provides a promising tool for timing interventions in sepsis-related multi-organ failures.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/68d5bd5ddc445aa9033afcc6https://doi.org/10.1097/shk.0000000000002704
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