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September 23, 2025

TACI Ig Fusion Protein Inhibits TLR4/MyD88/NF-κB Pathway Alleviates Renal Injury in IgA Nephropathy Rats

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Authors

JSJianhua SunYCYue ChengWZWei Zhang

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Overview

Experimental analysis shows TACI-Ig significantly reduces inflammation and renal damage by inhibiting TLR4/MyD88/NF-κB pathway.

Key Points

  • TACI-Ig treatment significantly reduced proteinuria and serum creatinine levels in IgAN rats, indicating improvement in kidney function.
  • The IgAN model shown increased levels of BAFF and APRIL, while TACI-Ig effectively lowered these inflammatory markers after 8 weeks.
  • Western blot and RT-qPCR confirmed that TACI-Ig suppressed TLR4/MyD88/NF-κB pathway, demonstrating its anti-inflammatory actions.
  • Pathological assessments revealed that TACI-Ig ameliorated glomerular damage and fibrosis, indicating its potential therapeutic effects in IgAN.

Cite This Study

Sun et al. (2024) studied this question.

synapsesocial.com/papers/68d441ad713b0b5dfea810a2https://doi.org/10.61882/ijkd.18.6.326
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