This research demonstrates how menthol enhances cholinergic agonist contractions in Ascaris suum, suggesting new treatment options for parasitic infections.
Key Points
Menthol significantly potentiates contractions of Ascaris suum induced by acetylcholine and pyrantel.
The effect of menthol as an allosteric modulator was confirmed through the use of an nAChR antagonist, monepantel.
Potential combined therapy with menthol and cholinergic agonists may reduce parasite resistance problems.
No direct contraction changes were observed with menthol alone, highlighting its modulatory role.