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September 23, 2025Open Access

scRNA-Seq Combined with scPagwas Analysis Identifies GNG7 as a Core Gene in Lung Adenocarcinoma

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Authors

HLHanyang LiuBHBeibei HanGLGuiting Liu

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Overview

Combining single-cell RNA sequencing and GWAS reveals GNG7 as pivotal in lung adenocarcinoma, implicating CD8+ T cells.

Key Points

  • GNG7 is identified as a core gene linked to effector CD8+ T cells, improving survival rates in lung adenocarcinoma patients.
  • CD8+ T cell abundance was found to correlate with survival and therapeutic response, indicating potential prognostic significance.
  • Analysis utilized single-cell RNA sequencing and genome-wide association study data to explore tumor heterogeneity and immune landscape.
  • Elevated GNG7 expression significantly enhanced survival outcomes, suggesting its role as a therapeutic target in lung adenocarcinoma.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68d440ac713b0b5dfea80203https://doi.org/10.21203/rs.3.rs-7388573/v1
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