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September 23, 2025International Journal of Molecular SciencesOpen Access

Hypoxia and Tissue Regeneration: Adaptive Mechanisms and Therapeutic Opportunities

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Authors

IVIsabel Cristina VásquezCDCecilia DominguezMSMaría José Fernández Sánchez

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Overview

Review highlights cellular effects of hypoxia on tissue regeneration, suggesting therapeutic directions for clinical settings.

Key Points

  • Hypoxia significantly influences both beneficial and harmful outcomes in tissue regeneration, affecting processes like fibrosis.
  • Research shows that hypoxia affects angiogenesis and stem cell activity, impacting repair mechanisms in various tissues.
  • The review analyzes how hypoxia's effects vary by type—acute, chronic, intermittent—and the implications for therapeutic opportunities.
  • Explorations of biomedical and pharmacological strategies to control hypoxia indicate potential advancements in regenerative medicine.

Cite This Study

Vásquez et al. (2025) studied this question.

synapsesocial.com/papers/68d440ac713b0b5dfea801b9https://doi.org/10.3390/ijms26199272
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Also Consider

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  1. 1Biological Regulation of HIF-1a and Its Role in Therapeutic Angiogenesis for Treatment of Ischemic Cardiovascular Disease2025
  2. 2Oxygenation and Temperature Conditioning Alter the Vascular Morphology of Microvascular Constructs.2025
  3. 3Stabilisation of HIF signalling extends epicardial activation and neonatal heart regeneration2025
  4. 4Dual Roles of Hypoxia-Inducible Factor 1 in Acute Lung Injury: Tissue-Specific Mechanisms and Therapeutic Modulation2025
  5. 5Hypoxia. Impact of Hypoxia on Various Organ Systems. The Role of Hypoxia in aging2025